guidelines for the housing of mice in scientific institutions EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. The normal total cholesterol level is 26.0-82.4 mg/dl. The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. <> Phone: (734) 763-8028 To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Guideline No. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. in. Use a clean cage when combining males from different litters to prevent territorial behavior. Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) Fax: (734) 936-3235 The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE Wean pups by 21 days of age in either breeding scheme. Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Unit for Laboratory Animal Medicine (ULAM) Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Ann Arbor, MI 48109 The . The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. GUIDELINES FOR RATS AND MICE . Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Not a departure. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Follow housing densities for the type of caging used. While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. endobj endobj Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. the draft guidelines for the housing of mice in scientific institutions. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. GUIDELINES FOR RATS AND MICE . However, rats and mice are social animals; and individual housing constitutes a stressful situation. 2800 Plymouth Road the draft guidelines for the housing of mice in scientific institutions. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> 2 0 obj Authorization for Animal Housing and Special Services Costs. ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. cage ("standard" rat cage). For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. OLAW FAQ G10, Guide pp 6-7. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Guidelines for Housing Capacity. Animal Care & Use Office (ACUO) Institutional Animal Care and Use Committee . Exceptions to this guideline require prior IACUC approval. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. %PDF-1.5 New arrival mice. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. GUIDANCE & OVERSIGHT Tumour 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. House males individually in these circumstances, or with females, if intending to breed. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Phone: (734) 764-0277 Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. Enclosures designed to cause minimum disturbance to the animals. guideline housing mouse scientific institution Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Group-house weaned males with their littermates only. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. It is suggested that the housing of laboratory rodents should be improved by the use of … It is suggested that the housing of laboratory rodents … Guidelines for Transgenic Research. When breeding, no more than 2 adults and 1 litter, regardless of the size of the litter, will be allowed in a 75 square inch ("standard" mouse) cage. 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. Do not recombine adult male mice (older than 5 weeks) that have been separated. Deviation from Guide should statement according to a locally established performance standard. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Copy Generated on: January 25, 2021, 5:38 am, Guidelines for Documenting Scientific Justification for Exceeding Cage Densities, Maximum Housing Densities for Rat and Mouse Cages, Guidelines on Anesthesia and Analgesia in Ruminants, Guidelines on Administration of Substances to Laboratory Animals, Guidelines on Use of Streptozotocin in Rodents, Guidelines on Adjuvant Use in Rabbits Rats and Mice, The Regents of the University of Michigan. Q�N���e9k��DjϋY�O��� �!�=� Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. This does not apply to: Littermates that have been cage mates since birth. endobj ANZCCART 2000 The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . This does not apply to: Littermates that have been cage mates since birth. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. 4 0 obj Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modifications have been studied. Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. Which can serve as hiding places and/or for climbing cages with 71 in2 floor space be! 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